TLR3 Signaling Isothiocyanate and D,L-Sulforaphane on Differential Effects of Phenethyl

Isothiocyanate and D,L-Sulforaphane on Differential Effects of Phenethyl

Inhibition of angiogenesis and endothelial cell functions are novel sulforaphane-mediated mechanisms in chemoprevention.

Sulforaphane, an aliphatic isothiocyanate, is a known cancer chemopreventive agent. Aiming to investigate antiangiogenic potential of sulforaphane, we here report a potent decrease of newly formed microcapillaries in a human in vitro antiangiogenesis model, with an IC50 of 0.08 micromol/L. The effects of sulforaphane on endothelial cell functions essential for angiogenesis were investigated in ...

Effects of iron and cupper ions on sulforaphane content and peroxidase activity in Lepidium draba seedlings

Sulforaphane (SFN) is an isothiocyanate which is produced through glucoraphanin hydrolysis via myrosinase activity. In the present study, SFN content and peroxidase activity has been assessed in treated Lepidium draba seedlings with different concentrations of iron and copper during 8 and 16 hours treatment. The results showed that the SFN content drastically elevated at treatment with...

The dietary isothiocyanate sulforaphane targets pathways of apoptosis, cell cycle arrest, and oxidative stress in human pancreatic cancer cells and inhibits tumor growth in severe combined immunodeficient mice.

Anticancer effects of the dietary isothiocyanate sulforaphane were investigated in the human pancreatic cancer cell lines MIA PaCa-2 and PANC-1. Sulforaphane-treated cells accumulated in metaphase as determined by flow cytometry [4C DNA content, cyclin A(-), cyclin B1(+), and phospho-histone H3 (Ser(10))(+)]. In addition, treated cells showed nuclear apoptotic morphology that coincided with an ...

Lung Adenomas Induced by Tobacco Carcinogens in A/J -Acetylcysteine Conjugates Inhibit Malignant Progression of N Phenethyl Isothiocyanate and Sulforaphane and their

We have shown previously that naturally occurring isothiocyanates derived from cruciferous vegetables and their N-acetylcysteine conjugates inhibit lung adenoma formation induced by tobacco carcinogens in A/J mice at the postinitiation stage. The tumor-inhibitory activity by these compounds is linked with activation of activator protein and induction of apoptosis in lung tissues, suggesting tha...